History of Sequora
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History of Sequora's Flagship Tool: Sequora Phylogenomics - Small Genome
Gregory S Muhs
Sequora began development in August 2024 with a simple goal: make full genome comparison easier for working microbiologists. I wanted a tool that could handle full bacterial genomes without requiring any programming knowledge. What started as a small project quickly grew into a broader platform for accessible, in-browser bioinformatics.
In short, I wanted Bioinformatics to be easy, and feel like a videogame, with tools made for microbiologists and other scientists, not just software engineers.
Sequora was built for microbiologists who need fast, straightforward genome comparisons—without the technical barriers. Many tools require installing software, writing code, or using the command line. Sequora runs entirely in the browser. Just upload your FASTA files and go—no setup, no programming.
Traditional phylogenetics relies on comparing one set of genes at a time, and different genes can give different evolutionary relationships. Depending on which outgroup you use, you can also get a different tree. This is part of why I wanted a full-genome phylogenomic comparison tool that went beyond traditional phylogenetics. I have also always been skeptical of forcing phylogenetic relationships into a tree-like structure. After all, horizontal gene transfer is common among bacteria, and convergence is a well-known phenomenon in nature.
Instead of comparing just a few genes, Sequora looks at whole genomes. This gives a more complete picture of how bacterial strains relate, especially in cases where horizontal gene transfer or gene convergence can distort single-gene trees. Full-genome comparison helps reveal meaningful patterns that traditional methods might miss.
Sequora now includes built-in tools for common bioinformatics tasks. You can align sequences, merge files, find genes, translate proteins, and generate reverse complements—all in one place. It’s designed to simplify your workflow, whether you’re tracking outbreaks or exploring strain diversity.
Sequora Phylogenomics - Small Genome Release History
Release 2.01 - 09 January 2025
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